healthUpdated: Dec 28, 2020, 10:56 ISTMount Sinai researchers claim to have discovered new measures to predict risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The study published in the research journal Gastroenterology shows that the polygenic risk scores, built using association data from multiple populations in Mount Sinai’s multi-ethnic BioMe Biobank, maximized IBD predictions for every population in the biobank. BioMe is a system-wide effort at Mount Sinai that is revolutionizing diagnosis and classification of diseases according to the patient’s molecular profile. Predictive power was lower for patients with African ancestry, likely due to substantially smaller reference datasets and substantially greater genetic diversity within populations of African descent. Future studies by the Cho Laboratory will focus on predicting which subsets of patients might benefit from targeting this pathway.

Source: Hindustan Times December 28, 2020 05:15 UTC