Washington: Researchers have discovered new drug compounds that target a protein which enables the novel coronavirus and other viruses with pandemic potential to replicate in human cells, an advance that may lead to new therapeutics for COVID-19. They said the compounds can disrupt the SKI protein complex in the human body which regulates various aspects of the functioning of a cell. "We also identified compounds that targeted the SKI complex, not only inhibiting coronaviruses but also influenza viruses and filoviruses, such as the one that causes Ebola," Frieman said. Using computer modelling, the researchers identified a binding site on the SKI complex and identified chemical compounds that could attach to this site. From further experimental analysis, they showed that these compounds have antiviral activity against coronaviruses, influenza viruses, and filoviruses such as Ebola.

Source: Mint November 15, 2020 06:56 UTC