Longevity-linked enzyme shown to regulate brain metabolism, opening drug and biomarker opportunities for aging-related neurological disease. A newly identified role for a longevity-linked brain enzyme could change how scientists – and investors – talk about neurodegenerative disease. More of it is pushed toward the kynurenine pathway. In fruit fly models lacking SIRT6, the team inhibited a second enzyme, TDO2, which plays a key role in directing tryptophan into the kynurenine pathway. Toiber explained that their findings established the enzyme SIRT6 as a critical target for pharmacological intervention against brain degeneration.

Source: The Hindu December 25, 2025 14:52 UTC