Ankylosing spondylitis is a chronic inflammatory disease that affects the medial joints and can lead to spinal deformity and loss of function to patients.IL-17, a key inflammatory cytokine in the pathogenesis of ankylosing spondylitis, has demonstrated good commercial value with its unique efficacy and safety advantages, and has become a new therapeutic target. Secukinumab and Ixekizumab, which have the same drug targets as AK111, have been approved by the Food and Drug Administration of the United States (FDA) for the treatment of ankylosing spondylitis. Gumokimab, being an independently developed and innovative drug in China, is expected to bring new hope to patients with ankylosing spondylitis in the future. Gumokimab is intended to be used for the treatment of diseases such as psoriasis and ankylosing spondylitis. Through combination of competitive blockers, namely IL-17A and IL-17R, and blocking the biological activities of IL-17, Gumokimab has reached the efficacy in immune-related diseases in clinical therapies.The clinical trial of Gumokimab, which involves multiple subcutaneous injections of escalating doses to subjects with moderate-to-severe plaque psoriasis, has completed.

Source: Ethiopian News December 29, 2021 02:47 UTC