Two-year-old Daisy Parker, from Seaton, Workington is the seventh person in the UK to be diagnosed with Shashi-Pena syndrome, an extremely rare neurodevelopmental disorder caused by mutations in the ASXL2 gene, which is thought to only affect around 55-60 people worldwide. The syndrome affects development in the body, with Daisy being unable to talk and walk, despite turning three in April of this year. (Image: Supplied)Speaking about what it's been like for the family since Daisy's diagnosis, Danielle said: "It's a bit of a weird one because we have got an answer now, but also we haven't. "We know she has got Shashi-Pena syndrome but we don't know what that means. Since her diagnosis, Daisy's family have started fundraising under the name 'Daisy’s Diamonds', walking 2 million steps in the month of August 2025, raising $2,749 for the ARRE Foundation.

Three generations of the same family are gearing up to skydive for a cause close to the hearts. Alicia Bell, 15, alongside her dad James, 39, and grandfather Simon Bearing, 69, will take a leap from Beccles Airfield on February 21. Simon Dearing, Alicia Bell and James Bell who are set to make a charity skydive for Autism Anglia. Picture: Mark BullimoreThe family are closing in on their £1,050 fund-raising goal for Autism Anglia, having raised over £800. “Autism Anglia is a charity that provides much needed help to people in a similar situation to us.

Examples of sexualized images generated by Grok include:Numerous images depicting people wearing transparent bikinis or micro-bikinis. Grok generated an estimated additional 9,900 cartoon sexualized images of childrenDuring the 11-day period studied, Grok generated an estimated 9,900 sexualized images depicting children in cartoon or animated form based on our sample. Of the 12,995 flagged posts, the manual review process identified 101 as containing sexualized images of children, and an additional 43 as containing non- photorealistic sexualized images of children. This corresponds to an estimated 23,338 photorealistic sexualized images of children, and 9,936 non-photorealistic sexualized images of children generated by Grok over the study period. Researchers ran the same process to estimate the 95% uncertainty interval for the prevalence of photorealistic sexualized images of children.

Act now to keep your subscriptionWe've tried to contact you several times as we haven't been able to take payment. You must update your payment details via My Account or by clicking update payment details to keep your subscription.

The people who would have been gifted before, remain gifted, and those who would not have been gifted, continue not to be. I would argue that the answer is “yes,” because Generative AI uniquely is doing some of the higher-level cognitive work, not merely the lower-level supportive cognitive work that supports the higher-level cognitive work. 16:1498132. doi: 10.3389/fpsyg.2025.1498132, PubMed Abstract | Crossref Full Text | Google ScholarKlingbeil, A., Grützner, C., and Schreck, P. (2024). doi: 10.1017/s0272263100000589 Crossref Full Text | Google ScholarRomán-González, M., and Pérez-González, J.-C. (2024). BMJ 391. doi: 10.1136/bmj.r2239, PubMed Abstract | Crossref Full Text | Google ScholarSturgeon, T. (1958).

'It's the ultimate long-term deal,' Trump says of Nato 'framework' on GreenlandIn response to a question from CNN at Davos today, the president said that his newly announced “framework of a future deal” on Greenland is “the ultimate long term deal”. “I think it puts everyone in a really good position,” Trump said. “Especially as it pertains to security and minerals and everything else.”When asked how long the deal is expected to last, the president said: “Infinite.”

AFC Henley over 50s maintained their Oxfordshire Veterans League promotion push with a solid 4-2 home win last Sunday. A blistering first half performance saw Henley race into a 3-0 lead. The second goal arrived when the league’s top scorer, Costa Onisor, rounded the goalkeeper following a through ball by Ian Plumpton. The second half was a much more open affair with the linesman’s flag denying Onisor a second goal. The visitors’ second goal gave them renewed energy and Henley saw the game through with a battling last15 minutes.

Virgil van Dijk spoke about Roberto De Zerbi after Liverpool beat Marseille in the Champions LeagueManchester United have received a ringing endorsement from Liverpool captains past and present, Steven Gerrard and Virgil van Dijk, for Roberto De Zerbi as speculation mounts over the managerial vacancy. The Marseille head coach has emerged as a leading contender to replace Ruben Amorim, who departed earlier this month. The pundit said on TNT Sports: "He's box office, he's box office. Read our Privacy PolicyVan Dijk also provided insight into what style United might adopt under De Zerbi's stewardship. Speaking after the match, the Liverpool skipper said: "It's always difficult to play against De Zerbi teams, I'll say it like that.

This is the second item in our 2026 culture special with reviews of artists' works with developmental relevance. War is raging in Syria, bombs are falling from the sky, people are starving and being buried in rubble, friends and relatives are dying. Father and son await the departure of their boat, together with other Syrians and people from Afghanistan, Somalia, Iraq and Eritrea. Mourning and melancholy mingle with fear of the terrors of the sea and the unknown. All of them have had to leave their countries in search of a new home abroad – well aware that they will be unwelcome guests there.

Act now to keep your subscriptionWe've tried to contact you several times as we haven't been able to take payment. You must update your payment details via My Account or by clicking update payment details to keep your subscription.

Now, reports are circulating that she is being replaced by TV cook Nigella Lawson. Nigella Lawson rumoured to replace Prue Leith on Great British Bake OffThe report comes from The Sun, which claims contract talks with Nigella are underway and "at the final stages". Nigella Lawson is a huge name in the world of TV cooking and has hosted her own cooking show series, Nigella Bites, on Channel 4 previously. TV cook Nigella Lawson is rumoured to be replacing Prue Leith on Bake Off (Image: Chenying Cannell/PA Wire)Other TV series include her ITV daytime chat show, Nigella and various BBC Two series, Nigella's Christmas Kitchen and Nigella Express, and more recently, Nigella’s Cook, Eat, Repeat. Would you like to see Nigella Lawson as the new Bake Off judge?

On a typical January morning, the Riverside Surgery feels unusually calm for a practice serving 24,000 patients across five sites. Many of us have come to dread the 8am rush to secure a GP appointment, but things are done very differently here. Dr Chinenye Ekpeh, a GP partner, is on duty. "It's about knowing who needs to be seen immediately, who needs to be seen today and minimising risks," Ekpeh says. "If someone needs to come in, we bring them in."

To celebrate, we have compiled a gallery of red squirrel shots from across Cumbria and the surrounding regions, click the main article image to view. The Red Squirrel Survival Trust celebrate the appreciation day, which aims to raise awareness of the plight of red squirrels in the UK and the actions being undertaken for their conservation. Cumbria is one of the last counties in England where red squirrels still survive in the wild. In 2024, the Keswick area saw numerous outbreaks of the fatal virus in red squirrel communities, each time seemingly wiping out most or all of the reds close by. Volunteer groups across Cumbria often head into the woods at first light, in all weathers, to monitor feeders, record sightings and humanely manage grey populations.

The Canadian Prime Minister’s argument tempered brutal realism— “we are in the midst of a rupture, not a transition” —with optimism. Carney was better placed than anyone in the world to have delivered such a speech. As Governor of the Bank of England, he watched as Britain committed what he privately considered to be a monumental act of stupidity with Brexit. Complementarities are positive sums.”What is depressing is that it is almost impossible to imagine Keir Starmer or any other British political leader delivering such a speech, even assuming they understood the arguments. Besides, in his decade at the front rank of UK politics, Starmer has never delivered a single notable speech.

Create your free account or sign in to continue your searchEmail or phone Password ShowSign in with EmailorNew to LinkedIn? Join nowBy clicking Continue to join or sign in, you agree to LinkedIn’s User Agreement, Privacy Policy, and Cookie Policy.