The p.Gly2019Ser was the only LRRK2 pathogenic variant found in this cohort. Certain regional trends were observed among PD patients, notably the shorter duration of illness in Upper Egypt compared to Lower Egypt. Around one third of PD patients who did not have the p.Gly2019Ser variant experienced symptoms before turning 50 years old. Interestingly, most p.Gly2019Ser carriers were of North African and Ashkenazi descent, and these ancestries were present in all p.Gly2019Ser carriers, confirming an ancient founding event in these populations. 2: A map illustrates that Egypt is centrally located in a region with the highest prevalence of the p.Gly2019Ser pathogenic variant globally.

Source: The North Africa Journal November 06, 2024 19:41 UTC