Women who have higher grade CIN also have a higher risk of cervical cancer and HPV-related conditions.1Researchers analyzed 18 studies to assess the risk of HPV infection or recurrent lesions (related to HPV infection after surgery) and the HPV vaccination. Of the 18 studies, 12 were observational, 4 post hoc analyses of randomized control trials (RCTs), and 2 RCTs, the latter of which were classified as having a low risk of bias. However, the observational and post hoc analyses had a mix of moderate, serious, and critical risk of biases.1Based on the data, the investigators observed that vaccinated individuals had a 57% lower risk of recurrent high grade preinvasive disease (CIN2+) compared to unvaccinated individuals. The decrease grew to 74% when the disease was related to HPV16 and HPV18, which are 2 high-risk HPV types associated with most cervical cancers. Patients also reduced their risk of recurrent higher grade CIN3 if they were vaccinated, but the evidence may not be fully qualified by scientists.1

Source: The Guardian August 07, 2022 16:54 UTC