Researchers determined that the N-terminal folded domain was able to bind to small host RNA and DNA pieces. “Elegant dance of destructive viral production’“These two things—RNA/DNA interactions and host interactions (cyclophilin-A)—are coupled in this dual-packaging process. Eisenmesser’s team uses nuclear magnetic resonance to identify these molecular interactions. Study finds potentially druggable process of SARS-CoV-2 replicationMore information:Jasmina S. Redzic et al, The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region, Journal of Molecular Biology (2021). Jasmina S. Redzic et al, The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region,(2021).

Source: The Guardian January 19, 2022 01:47 UTC