However, limited access to postmortem brain tissues from patients with PTSD restricted the characterization of brain-based molecular changes at the appropriate scale. The investigators also found an overlap between PTSD and MDD, with childhood trauma and suicide being the primary drivers of molecular variations in the 2 disorders. “We found that the brains of people with these disorders have molecular differences, especially in the prefrontal cortex. Researchers unveil shared and unique brain molecular dysregulations in PTSD and depression. Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood.

Source: New York Times June 05, 2024 21:00 UTC