Tokyo, Aug 26 (PTI) Scientists have developed an antibody that significantly suppresses malignant tumours in dogs, showing promise for safe and effective treatment of intractable cancers. In humans, some malignant cancer cells express PD-L1 proteins that bind to their receptor PD-1 on T cells, resulting in the suppression of the T cells immune function. Researchers from Hokkaido University in Japan developed a chimeric anti-PD-L1 antibody that induces immune responses and therefore tumour regression in dogs with malignant cancers. Researchers treated seven dogs with OMM and two dogs with undifferentiated sarcoma were treated with the chimeric antibody every two weeks. Although further clinical studies are needed, other PD-L1-positive cancers could be targeted by the antibody we have developed," said Satoru Konnai from Hokkaido University.

Source: India Today August 26, 2017 11:15 UTC