The San Francisco 49ers face potentially their most daunting test of the season Week 1 on the road against the Minnesota Vikings. Even then, San Francisco does have a favorable matchup against an injury-plagued and less-than-stellar Vikings offensive line. If they're able to open up holes on traditional run plays, it will be big for San Francisco. Multiple picks would make it nearly impossible for San Francisco to come out on top. San Francisco has a ton of tremendous weapons and matchups to look forward to in this one.

Source: Forbes September 08, 2018 19:07 UTC