The researchers detailed how the inflammatory cell death signaling pathway worked, which led to potential therapies to disrupt the process. "Understanding the pathways and mechanism driving this inflammation is critical to develop effective treatment strategies," said Kanneganti, vice chair of the St Jude Department of Immunology. We also identified the specific cytokines that activate inflammatory cell death pathways and have considerable potential for treatment of COVID-19 and other highly fatal diseases, including sepsis," she said. The cellular and molecular mechanisms that comprehensively define cytokine storm was also lacking. "The findings link inflammatory cell death induced by TNF-alpha and IFN-gamma to COVID-19," Kanneganti said.

Source: Mint November 21, 2020 03:33 UTC