Thus there are chances of immune response getting evoked leading to rejection when the decellularised cornea is transplanted. To overcome this problem, the team used a chemical (chondroitin sulphate) naturally found in a cornea to combine with the decellularised cornea. To test this they used cornea without removing any cellular or nuclear material, corneas with cellular and nuclear material removed and finally decellularised corneas with the chemical combined to them. “During in vitro studies we found some immune response in the case of decellularised corneas but decellularised corneas was conjugated [combined] with the chemical showed no immune response,” says Prof. Ghosh. “Decellularised cornea showed the most inflammation and blood vessel formation [vascularisation].

Source: The Hindu May 12, 2018 12:33 UTC