A team of US scientists have explored how the mutations inand Kappa variants of the Covid virus help the variants avoid recognition by antibodies.The scientists from the University of Washington School of Medicine obtained plasma samples from 37 individuals, ranging in age from 22 to 66, who had received either two doses of the Moderna or Pfizer/BioNtech or one dose of the Janssen Covid-19 vaccines.Their data demonstrated that the Delta, Kappa, and Delta Plus variants reduced virus neutralising potency from vaccine-induced antibodies.The Delta Plus variant caused the greatest decrease. Antibodies from half of the Janssen-vaccinated individuals completely lost the ability to neutralise one or more variants in the laboratory assay.Although the Kappa and Delta Plus variants were better able to evade vaccine-elicited antibody neutralisation, it was the Delta variant that became dominant worldwide.Vaccine developers have largely concentrated on targeting the spike glycoprotein on the surface of the Covid virus. The spike glycoprotein includes an N-terminal domain that enhances cell binding, and a receptor binding domain that engages with the ACE2 receptor on host cells.Most antibodies against the pandemic coronavirus latch onto specific sites on these two domains. Consequently, coronavirus variants have mutated their N-terminal domain and receptor binding domain to evade these antibodies, as is the case for the delta and kappa variants, the team said. This antibody takes an unusual angle of approach to make a unique contact footprint within the N-terminal domain.The discovery of broadly neutralising coronavirus antibodies is also informing new Covid-19 vaccine ideas and also helping scientists to work on next-generation vaccine candidates that might be able to produce broad immunity against sarbecoviruses.

Source: Economic Times November 11, 2021 17:57 UTC