Circulating recombinant forms (CRFs) and unique recombinant forms (URFs) constitute the highest proportion of circulating HIV-1 subtypes among key populations, according to results of a study published in The Journal of Infectious Diseases. Researchers performed a systematic literature review and meta-analysis to characterize HIV-1 and HIV-2 subtypes across geographic regions and key populations. The review included data on HIV-1 and HIV-2 subtype prevalence that were captured between January 2010 and June 2021. “ Among the hurdles facing HIV vaccine development is the global HIV-1 genetic diversity, where recombinants (CRFs and URFs) now constitute the highest proportion of circulating HIV while continuing to increase in prevalence. “Among the hurdles facing HIV vaccine development is the global HIV-1 genetic diversity, where recombinants (CRFs and URFs) now constitute the highest proportion of circulating HIV while continuing to increase in prevalence,” the researchers noted.

Source: The North Africa Journal September 12, 2023 15:36 UTC