A study has recently revealed that men who lack a certain gene subtype may be more susceptible to treatment-resistant prostate cancer. Researchers from Cleveland Clinic confirmed for the first time a mechanistic link between the gene HSD17B4 and deadly, aggressive prostate cancer. Lead researcher Nima Sharifi explained that they studied a related gene, called HSD17B4. Since androgens are essential for prostate cancer growth, inactivating them should prevent cancer advancement. While ADT is successful early on, it eventually fails, allowing the cancer to progress to a lethal phase called castration-resistant prostate cancer (CRPC).

Source: Hindustan Times January 17, 2018 11:26 UTC