A new daily pill could be a more effective GLP-1 tablet for weight loss, according to a clinical trial that may pave the way for an improved non-injection alternative to Wegovy and Mounjaro. The drug, called orforglipron and manufactured by Eli Lilly, is prescribed for type 2 diabetes and targets the same GLP-1 receptors as oral semaglutide. At present, semaglutide is the only GLP-1 medication for type 2 diabetes available in pill form in the US. However, oral semaglutide has been shown to be less effective for weight loss than semaglutide injections — such as Ozempic and Wegovy — or tirzepatide injections such as Mounjaro. Participants received either 12mg or 36mg of orforglipron, or 7mg or 14mg of oral semaglutide, over the course of a year.

Brentford hand Keith Andrews new SIX-YEAR contract as boss closes in historyBrentford have announced that their head coach Keith Andrews has signed a new contract committing him to the Bees until 2032 after enjoying a strong start to his managerial careerView 2 Images Keith Andrews has signed a new contract keeping him at Brentford until 2032 (Image: Jan Kruger)Brentford have handed Keith Andrews a new six-year contract to reward the Irishman for a stellar maiden campaign in charge at The Gtech Community Stadium. But Andrews has excelled in his first senior management role to leave fans dreaming of Europe. ‌Andrews currently has Brentford seventh in the Premier League standings, just five points off their neighbours, Chelsea, in fifth place. ‌“When Keith accepted the job last summer, he signed a three-year contract, but the intention was always that we’d review this at the earliest opportunity,” Giles said. ‌“Keith has done an outstanding job, the team are playing well and the things we thought we could be better at this season have all improved.

'After careful consideration, I have decided to step down as President and CEO of the World Economic Forum. Among the files were several emails that suggested Epstein and Brende held multiple meetings during 2018 and 2019. In the picture, Brende, Bannon, Norwegian diplomat Terje Rød-Larsen are standing together in a grand hallway. Epstein and Brende held another dinner together in September, and proceeded to send each other Christmas and birthday greetings in the following months. I really appreciated the dinner,' Brende replied.

State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington Washington D.C. West Virginia Wisconsin Wyoming Puerto Rico US Virgin Islands Armed Forces Americas Armed Forces Pacific Armed Forces Europe Northern Mariana Islands Marshall Islands American Samoa Federated States of Micronesia Guam Palau Alberta, Canada British Columbia, Canada Manitoba, Canada New Brunswick, Canada Newfoundland, Canada Nova Scotia, Canada Northwest Territories, Canada Nunavut, Canada Ontario, Canada Prince Edward Island, Canada Quebec, Canada Saskatchewan, Canada Yukon Territory, CanadaZip Code

State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington Washington D.C. West Virginia Wisconsin Wyoming Puerto Rico US Virgin Islands Armed Forces Americas Armed Forces Pacific Armed Forces Europe Northern Mariana Islands Marshall Islands American Samoa Federated States of Micronesia Guam Palau Alberta, Canada British Columbia, Canada Manitoba, Canada New Brunswick, Canada Newfoundland, Canada Nova Scotia, Canada Northwest Territories, Canada Nunavut, Canada Ontario, Canada Prince Edward Island, Canada Quebec, Canada Saskatchewan, Canada Yukon Territory, CanadaZip Code

However, the globetrotter insists that one overlooked city in Poland will always be his favourite. Having previously named Greece as his favourite overall destination, Gabriel said he believes the city would be even more impressive in warmer weather. During his winter visit, temperatures in the Baltic coastal city dropped to -1C, whereas summer temperatures typically reach a balmy 25C. Gdansk also hosts Europe's biggest Christmas market, The Craiova Christmas Market, every yearHe said: 'This grey overcast definitely doesn't result in the best conditions for filming and exploring. The Craiova Christmas Market is billed as the largest Christmas event in the continent by area, spanning over 280,000 square metres.

Chelsea given worrying Cole Palmer update as World Cup fears surfaceCole Palmer has struggled with fitness and form this season, as Chelsea navigate a campaign which for them started less than a month after winning the Club World CupView 2 Images Cole Palmer has been described as 'shattered' (Image: Justin Setterfield/Getty Images)Cole Palmer has been left ’shattered’ and Chelsea are suffering from severe burnout. Palmer played a full season in 2023-24, then went to the Euros in 2024 and did not get a proper break last summer as he played for Chelsea in the Club World Cup. ‌That has left Palmer in serious danger of missing this summer’s World Cup with England because he has not made Thomas Tuchel’s squad since last June. ‌Talking at the FT Live event, Molango said: “For us the concern is, of course, player welfare because for me when I look at someone like Cole Palmer. Cole Palmer could go if he goes to the World Cup three consecutive summers without a break.

WRU announce major new appointment in £160,000 role as Gatland's man returnsThe WRU have made a key appointment as a familiar face returns to Welsh rugbyView Image Rhys Long, right, with Warren Gatland (Image: Getty Images)One of English football’s leading analysts, Rhys Long, has been appointed as the Welsh Rugby Union's new technical director. ‌Long joins Welsh rugby from the role of Head of Performance Analysis and Technical Insights at the Football Association and brings over 20 years of experience at the highest level in sport. ‌His new job comes with a salary of up to £160,000 a year and he will report directly to elite performance director Dave Reddin. ‌“This is an important time to join Welsh rugby, we are in a period of transition but bold steps towards a successful future have already been taken,” he said. “As a passionate Welshman, Rhys is emotionally invested in the journey we are on and brings a unique combination of skills and experiences which I believe will significantly enhance our capability, capacity and connection across the Welsh rugby system."

There was renewed confusion on Thursday regarding whether or not the Defence Forces would have counter-drone technology before Ireland assumes the EU presidency in July when defence minister Helen McEntee confirmed it would not arrive until September. Two weeks ago, the Irish Examiner reported that the updated implementation plan for the Commission on Defence Forces stated that the counter-drone technology would not be in place until September. Ms McEntee said gardaí already have “significant” counter-drone technology. The navy ship had no counter-drone technology to disable the drones. Ms McEntee said that An Garda Síochána, Air Traffic Control and the Defence Forces “have been doing a review of essentially what happened”.

‌Premier League chief executive Richard Masters revealed they are starting the new project by launching a new direct-to-viewer streaming service with broadcaster StarHub in Singapore. That will act as a pilot for the Premier League + channel and it will show all 380 games live as well as magazine content starting next season. ‌There is currently a 3pm blackout in the UK but foreign deals would be exempt from rules showing games live on a Saturday. So from next season onwards, Premier League + – rather than Premflix – finally, it’s going to happen. But that could soon change with the Premier League looking to take charge of its own rights.

With their bellies full of bread, leaving little room for real food, they risk becoming undernourished in the midst of plenty. But adults and children love feeding ducks and swans. Bread feeding may be criticised but it’s a marvellous experience for children. During the 1980s and 90s, I purchased sack-loads of discarded bread from a local grocer and fed it to swans in Dublin and Wicklow. There was little evidence of serious adverse effects from bread feeding among the swans.

One of the nicest views is from the kitchen window at the back of the house, facing south, looking out over fields of green that stretch endlessly into the distance. Below the window is a large, wraparound flagstone patio that gets the best of the light all day. Sharon says the fields were kept in great shape by her farmer husband, with whom she built the house in 1992. Off the kitchen is a family room where double doors open to the patio. Across the hall is a downstairs double bedroom, Sharon’s art studio (possible fifth bedroom?

Discount supermarket Lidl has received the green light from the local council for a new €200m regional distribution centre outside Cork City. The new unit, located in Wallingstown, Little Island, will mark Lidl's fourth in the Republic of Ireland and the second to be located in Cork. Last year, the German company announced a fresh investment of €600m in developing 35 new stores, along with the Little Island distribution centre. Lidl currently services 190 stores in the Republic from its three regional distribution centres at Charleville in North Cork, Mullingar, and Newbridge. It currently operates 52 stores across Munster, including 22 in Cork, six in Limerick, four in Waterford, and eight in Kerry.

More of the same is predicted due to climate change and, experts advise, people need to do much more in their homes. A recent survey found that one-fifth of EU homes do not have any household measures to protect against extreme weather. But, in various studies, one of the most pressing issues identified is the lack of urgency in preparing for weather crises. Climate change is often perceived by people as a distant concern rather than an immediate crisis requiring coordinated action. Costs of dealing with climate change issues are currently estimated at up to €800 million per year and are projected to rise into the billions by 2050.

Death of former Irish Ambassador from AthloneFrank Sheridan, who grew up in Athlone and went on to have a highly successful career in international diplomacy, including serving for spells as Ireland's Ambassador to Mozambique and Brazil, has died. Mr Sheridan, whose wife Rita (nee Tighe) is also from the Athlone area, passed away peacefully in the care of the staff of the Beacon Hospital last Saturday, February 21. He had been living in Bray following his retirement from the Department of Foreign Affairs in 2014, after he had been serving as the Irish Ambassador to Brazil. He returned to Ireland in 1998, but was on the move again in 2005 when he took up his first post as an Irish Ambassador, in Mozambique. He spent five years there before moving continents, in 2010, to become the Irish Ambassador to Brazil, a role he held until retirement in 2014.