What little slip-ups can be attributed to normal brain aging, and what can signify something more serious? We spoke with doctors to find out:AdvertisementBrain Changes To Expect Once You Hit Your 50sIn your 50s, your brain is already shrinking. “Cognitive decline can occur due to a sudden drop in hormones, such as the drop in estradiol associated with menopause. AdvertisementBredesen noted that issues that are more likely to pop up in your 60s, such as heart disease and chronic inflammation, can further contribute to cognitive decline. Normal Signs Of An Aging Brain — And When To WorryIt’s normal to experience some cognitive decline as we age.